Fri 13 May
10.45 – 11.00 Welcome
11.00 – 12.45 Session 1: From transcription to translation
- Reuven Agami (NKI) Sloppiness in mRNA translation in cancer and its impact on immunotherapy
- Esther Creemers (AMC) The RNA binding protein Quaking governs a muscle-specific splicing program in the heart
- Marvin Tanenbaum (Hubrecht Institute) Heterogeneity in genetic decoding
- Short talk: Yuval Malka (NKI) Alternative cleavage and polyadenylation generates downstream uncapped RNA isoforms with translation potential
12.45 – 13.30 Lunch and sponsor’s presentation
13.30 – 15.00 Session 2: RNA-mediated disease mechanism
- Monika Wolkers (Sanquin) Regulation of T cell function through post-transcriptional events
- Yael Nossent (LUMC) Modifications of small RNAs in cardiovascular disease
- Short talk: Truus Abbink (VU Amsterdam) From translation to transcription: a deregulated integrated stress response in the leukodystrophy vanishing white matter
- Short talk: Alzbeta Chabronova (Maastricht University) Differential 2’-O-methylation of U14 in 5.8S rRNA affects translation regulation and promotes a disease cellular phenotype
15.00 – 15.30 Coffee break
15.30 – 17.00 Session 3: RNA-based therapeutics
- Ype Elgersma (Erasmus MC) Towards ASO therapies for neurodevelopment disorders
- Elizabeth Rosado Balmayor (Maastricht University) Potential orthopedic applications of chemically modified RNA
- Short talk: Tooba Abbassi-Daloii (LUMC) A transcriptome atlas of leg muscles from healthy human volunteers reveals molecular and cellular signatures associated with muscle location
- Short talk: Lise Ripken (RadboudUMC) The dose makes the poison? Studying expanded triplet repeat mRNA in DM1 myoblasts using CRISPR/Cas9
17.00 – 18.00 Keynote: Prof Alexander Van Oudenaarden (Director, Hubrecht Institute) Novel sequencing tools to explore transcription and translation in individual cells
18.00 – 20.00 Poster session and drinks/snacks
Saturday 14 May
09.00 – 09.30 Welcome coffee
09.30 – 11.00 Session 4: RNA biology in viruses and the immune system
- Ronald van Rij (Radboudumc) Small RNAs at the nexus of antiviral immunity and development in vector mosquitoes
- Danny Incarnato (University of Groningen) High-throughput discovery of static and dynamic RNA structure elements
- Short talk: Lucas Picavet (Utrecht UMC) M6A reader YTHDC1 regulates nuclear export of methylated TNF transcripts in activated monocytes
- Short talk: Jorn Stok (LUMC) RNA sensing via the RIG-I-like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency
11.00 – 11.30 Coffee break
11.30 – 13.00 Session 5: Advances in RNA technologies
- William Faller (NKI) Trash or treasure? Using rRNA sequencing reads to understand the ribosome
- Peter-Bram ‘t Hoen (Radboudumc) The expanding transcript isoform landscape: from identification to function
- Short talk: Yvonne Jongejan (LUMC) Small interfering RNA-mediated allele-selective silencing of murine von Willebrand factor
- Short talk: Willem Velema (Radboudumc) Chemical Tools for RNA
13.00 – 13.30 Congress closing remarks